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  • 马淑梅
  • 作者:  编辑:肖丽彬  来源:   浏览:; 时间:2019年09月29日 16:01

  • 姓名

    马淑梅

    性别

    出生年月

    1971年11月

    职称

    教授

    学历

    医学科学博士

    学位

    博士

    研究方向

    放射医学/辐射肿瘤学与肿瘤转化医学/放射卫生学

    所在学科

    劳动卫生与环境卫生放射卫生

    电子邮箱

    shmm2001@ 126.com

    简历
    (从大学起)

    起止年月

    学习院校/工作单位

    专业/学位/职务

    1990.9-1995.7

    哈尔滨医科大学预防医学专业

    医学学士

    1995.9-1998.7

    白求恩医科大学卫生毒理学专业

    医学硕士

    1998.7-2000.9

    白求恩医科大学预防医学院

    助教

    1999.8-2001.7

    吉林大学白求恩医学部放射医学专业

    医学博士

    2000.9-2004.9

    吉林大学公共卫生学院

    讲师

    2002.10-2004.10

    吉林大学教育部分子酶学重点实验室

    博士后

    2003.10-2006.11

    加拿大曼尼托巴大学医学院免疫学专业

    博士后

    2004.9-2009.12

    吉林大学公共卫生学院

    副教授,硕士生导师

    2008.12-2010.3

    加拿大大不列颠哥伦比亚大学(UBC)肿瘤研究中心

    访问学者

    2009.12-2016.11

    吉林大学公共卫生学院

    教授,硕士生导师

    2013.10-2016.10

    加拿大曼尼托巴省肿瘤研究中心

    访问学者

    2016.12-2018.3

    吉林大学公共卫生学院

    教授,博士生导师

    2018.3-现在

    幸运pk10

    教授,博士生导师

    获得项目

    1. 国家重点研发计划“数字诊疗装备研发”重点专项(2017YFC010860346万元):质子重离子辐射生物学效应评估技术研究2017-2019,课题负责人

    2. 国家自然科学基金面上项目 (8187255858万元): xCT在辐射诱导的细胞损伤及铁死亡中的作用及调控机制,2019/01-2022/12,负责人

    3. 国家自然科学基金面上项目 (8167309270万元): 脱氧胞苷激酶dCK在电离辐射诱导自噬中的调控作用,2017/01-2020/12,负责人

    4. 国家自然科学基金面上项目(31370837, 80万)dCKCdk1相互作用对辐射诱导的细胞周期G2/M期检查点激活的调控机制,2014-2017,负责人

    5. 国家自然科学基金项目(81573082, 84万):电离辐射作用后溶酶体介导的细胞死亡机制研究,2016-2019第二名

    6. 吉林省科技厅项目2012050104万)细胞自噬在结直肠癌发生中的作用及其调控机制的研究。2012-2014负责人

    7. 吉林大学种子基金2分割剂量放疗联合p53突变子基因治疗逆转肿瘤多药耐药2009-2010负责人

    8. 吉林大学种子基金36.5恶性肿瘤发生及早期诊断、预后分析和综合治疗的分子基础2011-2013 负责人

    9. 吉林大学种子基金2分割剂量放疗联合p53突变子基因治疗逆转肿瘤多药耐药2011-2013 负责人

    10. 吉林大学科学前沿与科学交叉创新项目5Hsa-miR-21对宫颈癌细胞放射敏感性的影响及其机制研究2011-2013 负责人

    11. 吉林省卫生厅课题(1.5万):放疗联合p53突变子基因治疗逆转肿瘤多药耐药实验研究;2009-2010,负责人

    12. 惠恒科研基金项目(横向课题,10万):应用伽玛刀剂量梯度曲线对肿瘤组织杀伤效应2007-2009,负责人

    发表文章

    1. S Ma, E S Henson, Y Chen and S B Gibson. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death and Disease (2016) 7, e2307.

    2. Shumei Ma, Rebecca F. Dielschneider, Elizabeth S. Henson, Wenyan Xiao, Tricia R. Choquette, Anna R. Blankstein, Yongqiang Chen, Spencer B. Gibson. Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells.PLoS One. 2017; 12(8): e0182921

    3. Anna R. Blankstein, Shumei Ma and Spencer B. Gibson.Siramesine and lapatinib induce ferroptosis in glioblastoma and lung adenocarcinoma cells.Cancer Res July 1 2017 (77) (13 Supplement) 4293.

    4. Zhong R, Liang B, Xin R, Zhu X, Liu Z, Chen Q, Hou Y, Jin Z, Qi M, Ma S, Liu X.Deoxycytidine kinase participates in the regulation of radiation-induced autophagy and apoptosis in breast cancer cells.Int J Oncol. 2018 Mar;52(3):1000-1010.

    5. Zhong R, Xin R, Chen Z, Liang N, Liu Y, Ma S, Liu X.The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death.Int J Mol Sci. 2016 Nov 21; 17(11).

    6. Chen Z, Liu X, Ma S. The Roles of Mitochondria in Autophagic Cell Death.Cancer Biother Radiopharm. 2016 Oct; 31(8):269-276.

    7. Liang B, Liu X, Liu Y, Kong D, Liu X, Zhong R, Ma S. Inhibition of autophagy sensitizes MDR-phenotype ovarian cancer SKVCR cells to chemotherapy.Biomed Pharmacother. 2016 Aug;82:98-105.

    8. Cui L, Song Z, Liang B, Jia L, Ma S, Liu X.Radiation induces autophagic cell death via the p53/DRAM signaling pathway in breast cancer cells.Oncol Rep. 2016 Jun;35(6):3639-47.

    9. Yu F, Chen Z, Wang B, Jin Z, Hou Y, Ma S, Liu X.The role of lysosome in cell death regulation. Tumour Biol. 2016 Feb;37(2):1427-36.

    10. Chen Z, Wang B, Yu F, Chen Q, Tian Y, Ma S, Liu X. The roles of mitochondria in radiation-induced autophagic cell death in cervical cancer cells.Tumour Biol. 2016 Mar;37(3):4083-91.

    11. Wang B, Chen Z, Yu F, Chen Q, Tian Y, Ma S, Wang T, Liu X. Hsp90 regulates autophagy and plays a role in cancer therapy. Tumour Biol. 2016 Jan;37(1):1-6.

    12. Liang N, Zhong R, Hou X, Zhao G, Ma S, Cheng G, Liu X. Ataxia-telangiectasia mutated (ATM) participates in the regulation of ionizing radiation-induced cell death via MAPK14 in lung cancer H1299 cells.Cell Prolif. 2015 Oct;48(5):561-72.

    13. Zhao Y, Liu X, Zhong L, He M, Chen S, Wang T, Ma S. The combined use of miRNAs and mRNAs as biomarkers for the diagnosis of papillary thyroid carcinoma.Int J Mol Med. 2015 Oct;36(4):1097-103.

    14. Chen S, Zhu J, Yu F, Tian Y, Ma S, Liu X. Combination of miRNA and RNA functions as potential biomarkers for gastric cancer. Tumour Biol. 2015 Dec;36(12):9909-18.

    15. Zhong R, Xu H, Chen G, Zhao G, Gao Y, Liu X, Ma S, Dong L.The role of hypoxia-inducible factor-1α in radiation-induced autophagic cell death in breast cancer cells.Tumour Biol. 2015 Sep;36(9):7077-83.

    16. Zhao Y, Zhong R, Sun L, Jia J, Ma S, Liu X. Ionizing radiation-induced adaptive response in fibroblasts under both monolayer and 3-dimensional conditions.PLoS One. 2015 Mar 25;10(3):e0121289.

    17. He M, Zhao Y, Yi H, Sun H, Liu X, Ma S. The combination of TP53INP1, TP53INP2 and AXIN2: potential biomarkers in papillary thyroid carcinoma.Endocrine. 2015 Mar;48(2):712-7.

    18. Jia L, Ma S, Hou X, Wang X, Qased AB, Sun X, Liang N, Li H, Yi H, Kong D, Liu X, Fan F. The synergistic effects of traditional Chinese herbs and radiotherapy for cancer treatment. Oncol Lett. 2013 May;5(5):1439-1447. (共同第一作者)

    19. Min Liu, Shumei Ma, Mingbo Liu, Yufei Hou, Bing Liang, Xu Su, Xiaodong Liu.Synergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis.Oncol Lett. 2014june;7(6):1903-1910 (共同第一作者)

    20. Yang C, Lee M, Hao J, Cui X, Guo X, Smal C, Bontemps F, Ma S, Liu X, Engler D, Parker WB, Xu B. Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage. Nucleic Acids Res. 2012 Oct;40(19):9621-32.

    21. Liang N, Jia L, Liu Y, Liang B, Kong D, Yan M,Ma S, Xiaodong Liu X. ATM pathway is essential for ionizing radiation- induced autophagy. Cellular Signalling.2013 Dec;25(12):2530-9(并列通讯).

    22. Wang T,M SM,Kong D,Yi H, Wang X, Liang B, Xu H, He M, Jia L, Qased AB, Yang Y,Liu X.Effectofionizingradiationonacinarmorphogenesisof human prostaticepithelialcell underthree-dimensionalculture conditions. Neoplasma. 2012;59(3):269-81. (共同第一作者)

    23. Kong D, Ma S, Liang B, Yi H, Zhao Y, Xin R, Cui L, Jia L, Liu X, Liu X. The different regulatory effects of p53 status on multidrug resistance are determined by autophagy in ovarian cancer cells. Biomed Pharmacother. 2012 Jun;66(4):271-8. (共同第一作者)

    24. Qased AB, Yi H, Liang N, Ma S, Qiao S, Liu X. MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells. Mol Med Rep. 2013 Feb;7(2):559-64.

    25. Guanghui C, Dejuan K, Xue H, Bing L, Mengzi H, Nan L, Shumei M, Xiaodong L. The Tumor Suppressor, p53, Contributes to Radiosensitivity of Lung Cancer Cells by Regulating Autophagy and Apoptosis. Cancer Biother Radiopharm. 2013 Mar;28(2):153-9

    26. Ma S, Kong B, Liu B, Liu X. Biological effects of low-dose radiation from computed tomography scanning. Int J Radiat Biol.2013 May;89(5):326-33 (第一作者)

    27. Liang B, Kong D, Liu Y, Liang N, He M, Ma S, Liu X. Autophagy inhibition plays the synergetic killing roles with radiation in the multi-drug resistant SKVCR ovarian cancer cells. Radiat Oncol. 2012 Dec 17;7:213-224.(共同通讯作者)

    28. Yi H, Liang B, Jia J, Liang N, Xu H, Ju G, Ma S, Liu X. Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells. FEBS Lett. 2013 Mar 1;587:436-443.(共同通讯作者)

    29. Liu X, He M, Hou Y, Liang B, Zhao L, Ma S, Yu Y, Liu X. Expression profiles of microRNAs and their target genes in papillary thyroid carcinoma. Oncol Rep. 2013 Apr;29(4):1415-20.(共同通讯作者)

    30. Ma S, Jiao B, Liu X, Yi H, Kong D, Gao L, Zhao G, Yang Y, Liu X. Approach to radiation therapy in hepatocellular carcinoma. Cancer Treat Rev. 2010 Apr;36(2):157-63. (第一作者)

    31. Ma S, Liu X, Jiao B, Yang Y, Liu X. Low-dose radiation- inducedresponses:focusingonepigeneticregulation. Int J Radiat Biol.2010 Jul; 86(7):517-28. (共同第一作者)

    32. Ma S, Liu G, Sun Y, Xie J.Relocalization of the polypyrimidine tract binding protein during PKA-induced neurite growth. BBA-Molecular Cell Research,2007, 1773(6):912-923. (第一作者)

    33. Sun Y, Mu Y, Ma S, Gong P, Yan G, Liu J, Shen J, Luo G .The molecular mechanism of protecting cells against oxidative stress by 2-selenium-bridged beta-cyclodextrin with glutathione peroxidase activity. Biochim Biochim Acta . 2005, 1743(3):199-204

    34. Liu XD, Ma SM, Liu Y, Liu SZ, Sehon A .Short hairpin RNA and retroviral vectormediated silencing of p53 in mammalian cells. Biochem. Biophys. Res. Commun., 2004,32,1173-1178.

    35. Liu XD, Ma SM, Liu SZ. Effects of 0.075 Gy x-ray irradiation on the expression of IL-10 and IL-12 in mice. Phys Med Biol. 2003, 7; 48(13):2041-9

    荣誉及人才称号
    (校级及以上)

     

    学术兼职

    中华放射医学与防护杂志,编委

     

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